Molecular networks represent the backbone of molecular activity within cells and provide opportunities for understanding the mechanism of diseases. 2013 Oct 8;4(1):24. doi: 10.1186/2041-1480-4-24. Authors Christian Knüpfer 1 , Clemens Beckstein. Table,Based on the condition-specific CePINs, we propose a new analysis approach to identify condition-specific functional modules. For other uses, see,Holmes, Philip. This analysis included several steps of functional module discovery and selection, as illustrated in Figure,To further retain significantly denser functional subnetworks, we tested the functional homogeneity of each significant functionally enriched gene sets in respect to CePPIs. Signals transmitted by hormones, growth factors, neighboring cells or the extracellular matrix are sensed by cells and can trigger rapid changes in metabolism, gene expression, cell shape/cytoskeletal organization, … 2000, 86: 1107-1113.Ervasti JM, Ohlendieck K, Kahl SD, Gaver MG, Campbell KP: Deficiency of a glycoprotein component of the dystrophin complex in dystrophic muscle. This manuscript is thus the first of a fully new diptych containing a comprehensive presentation of our current vision of dFC as a random walk in FC space with complex spatiotemporal structure.Thank you for your interest in spreading the word about bioRxiv.NOTE: Your email address is requested solely to identify you as the sender of this article.The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.Enter multiple addresses on separate lines or separate them with commas.This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.Dynamic Functional Connectivity between Order and Randomness and its Evolution across the Human Adult Lifespan,Université Aix-Marseille, INSERM UMR 1106, Institut de Neurosciences des Systèmes,Institut de biologie de l’Ecole normale supérieure (IBENS), École Normale Supérieure, CNRS, INSERM, PSL Université Paris,Brain Simulation Section, Department of Neurology, Charité Universitätsmedizin and Berlin Institute of Health,Bernstein Center for Computational Neuroscience,Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam. COVID-19 is an emerging, rapidly evolving situation.This site needs JavaScript to work properly. Mol Syst Biol. For technical details, see,"Dynamical" redirects here. The dynamics of these modules between normal and disease states further suggest a potential molecular model of dilated cardiomyopathy.We propose a novel framework to analyze the interaction networks in different biological states. The traditional paradigm in brain research focuses on exploring the temporal dynamics and role of individual brain rhythms, and their association with specific physiologic states and functions 1,10. In this sense, they are static. 1991, 66: 1121-1131. These observations imply the negative regulation of growth factor signaling involving insulin and insulin-like growth factor. : Genomic expression profiling of human inflammatory cardiomyopathy (DCMi) suggests novel therapeutic targets. 10.1073/pnas.96.24.14025,Bostick B, Yue Y, Long C, Duan D: Prevention of dystrophin-deficient cardiomyopathy in twenty-one-month-old carrier mice by mosaic dystrophin expression or complementary dystrophin/utrophin expression. 2006, 34: D535-539. 2004, 82: 308-316. Cell. 10.1038/345315a0,Li J, Lenferink AEG, Deng Y, Collins C, Cui Q, Purisima EO, O'connor-Mccourt MD, Wang E: Identification of high-quality cancer prognostic markers and metastasis network modules.
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