Mol Immunol 44(10):2761–2771.Kumar O, Sugendran K, Vijayaraghavan R (2003) Oxidative stress associated hepatic and renal toxicity induced by ricin in mice. Separation, reassociation and pharmacological properties. Hum Vaccin Immunother 5:1196–1201.Buonocore C, Alipour M, Omri A, Pucaj K, Smith MG, Suntres ZE (2011) Treatment of ricin A-chain-induced hepatotoxicity with liposome-encapsulated N-acetylcysteine. Toxins (Basel) 9(10):pii: E314.Ferdous AJ, Stembridge NY, Singh M (1998) Role of monensin PLGA polymer nanoparticles and liposomes as potentiator of ricin A immunotoxins,Ferraz AC, Angelucci MEM, Da Costa ML, Batista IR, de Oliveira BH, da Cunha C (1999) Pharmacological evaluation of ricinine, a central nervous system stimulant isolated from,Ferraz AC, Anselmo-Franci JA, Perosa SR, de Castro-Neto EF, Bellissimo MI, de Oliveira BH, Cavalheiro EA, Naffah-Mazzacoratti MDG, da Cunha C (2002) Amino acid and monoamine alterations in the cerebral cortex and hippocampus of mice submitted to ricinine-induced seizures. J Insect Sci 6:30 (online: [insectscience.org/6.30]),Vitetta E (2006) Biomedical and biodefense uses for ricin. Les graines de ricin retrouvées dans les tombeaux égyptiens étaient utilisées pour extraire de l’huile destinée à l’éclairage.Quant à la graine, elle est très toxique, on considère en général qu’une à deux graines mâchées par un enfant ou 8 graines mâchées par un adulte peuvent leur être fatal. graines de ricin. moins de vouloir provoquer l'accouchement lorsque la grossesse arrive à son Artwork by courtesy of Dr. Jens Grosche (Effigos AG).Ricin is internalized through clathrin-dependent and clathrin-independent endocytosis. The advantages of quantitating ricinine as opposed to historical ELISA and radioimmunoassay methods that detect ricin itself [18–21] are rapid turn-around and ability to process large number of samples. Plant Sci 73(2):253–256,Olsnes S (2004) The history of ricin, abrin and related toxins. Toxichem Krimtech 85(3):97–99,Weber M, Schulz H (2011) Immunological detection of ricin and castor seeds in beverages. Diac, M.C. Another toxin called ricinine, an alkaloid, is also produced by this plant. Ricinine definition is - a crystalline compound C8H8N2O2 derived from pyridone and obtained from castor beans. Environ Helth Perspekt 107:975–984,Byers VS, Rodvien R, Grant K, Durrant LG, Hudson KH, Baldwin RW, Scannon PJ (1989) Phase I study of monoclonal antibody-ricin A chain immunotoxin XomaZyme-791 in patients with metastatic colon cancer. Int J Pharm 350:79–94.Tchou-Wong KM, Roy CJ, Parent C, Cabrera M, Guillemain J, Mac Loughlin R, Levacher E, Fontayne A, Douziech-Eyrolles L, Junqua-Moullet A, Guilleminault L, Thullier P, Guillot-Combe E, Vecellio L, Heuzé-Vourc'h N (2016) Development of a drug delivery system for efficient alveolar delivery of a neutralizing monoclonal antibody to treat pulmonary intoxication to ricin. What do the results of these tests tell us?
J Biochem 124:1038–1044.Korcheva V, Wong J, Corless C, Iordanov M, Magun B (2005) Administration of ricin induces a severe inflammatory response via nonredundant stimulation of ERK, JNK, and P38 MAPK and provides a mouse model of hemolytic uremic syndrome.
J Neurocytol 16:601–611,Herrera L, Bostrom B, Gore L, Sandler E, Lew G, Schlegel PG, Aquino V, Ghetie V, Vitetta ES, Schindler J (2009) A phase 1 study of Combotox in pediatric patients with refractory B-lineage acute lymphoblastic leukemia. Cancer Res 51:4052–4058,Vitetta ES, Smallshaw JE, Coleman E et al (2005) A pilot clinical trial of a recombinant ricin vaccine in normal humans. Chem Pharm Bull (Tokyo) 31:3222–3227,Iversen TG, Frerker N, Sandvig K (2012) Uptake of ricinB-quantum dot nanoparticles by a macropinocytosis-like mechanism. PMID 3711116,Singh A, Kaur J (2017) Activity of foliage extracts of,Singh M, Griffin T, Salimi A, Micetich RG, Atwal H (1994) Potentiation of ricin A immunotoxin by monoclonal antibody targeted monensin containing small unilamellar vesicles. Biosci Biotechnol Biochem 64:1422–1429,Hassan Y, Ogg S, Ge H (2018) Expression of novel fusion antiviral proteins ricin a chain-pokeweed antiviral proteins (RTA-PAPs) in,Hauschild F (1960) Pharmakologie und Grundlagen der Toxikologie, 2nd. Anti-chain A and B antibodies have shown encouraging results in animals and may be the basis for future immunoassays. Since then, ricin has been classified as a Class A biological weapon.The cytotoxic activity of ricin has been used experimentally in anti-cancer therapies by binding chain A to a monoclonal antibody. Blood 85:3457–3465,Scarpa A, Guerci A (1982) Various uses of the castor oil plant (,Schindler J, Gajavelli S, Ravandi F, Shen Y, Parekh S, Braunchweig I, Barta S, Ghetie V, Vitetta E, Verma A (2011) A phase I study of a combination of anti-CD19 and anti-CD22 immunotoxins (Combotox) in adult patients with refractory B-lineage acute lymphoblastic leukaemia. Toxicol Appl Pharmacol 138(1):72–76.Madan S, Ghosh PC (1992) Enhancing potency of liposomal monensin on ricin cytotoxicity in mouse macrophage tumor cells. Am J Pathol 166(1):323–339.Korcheva V, Wong J, Lindauer M, Jacoby DB, Iordanov MS, Magun B (2007) Role of apoptotic signaling pathways in regulation of inflammatory responses to ricin in primary murine macrophages. est présente dans toute la plante, mais sa concentration est maximale dans les Toxicol Rev 22(1):65–70.Brey RN III, Mantis NJ, Pincus SH, Vitetta ES, Smith LA, Roy CJ (2016) Recent advances in the development of vaccines against ricin. Chistol, A. Knieling. Pharmacol Biochem Behav 72:779–786,Fidias P, Grossbard M, Lynch TJ Jr (2002) A phase II study of the immunotoxin N901-blocked ricin in small-cell lung cancer. Cancer Lett 84:15–21,Singh M, Ferdous AJ, Kanikkannan N, Faulkner G (2001) Stealth monensin immunoliposomes as potentiator of immunotoxins,Slominska-Wojewodlzka M, Sandvig K (2013) Ricin and ricin-containing immunotoxins: insights into intracellular transport and mechanism of action.Smallshaw JE, Richardson JA, Pincus S, Schindler J, Vitetta ES (2005) Preclinical toxicity and efficacy testing of RiVax, a recombinant protein vaccine against ricin.
alkaloids: the modulation of voltage-dependent Na+ channels, toxicity and antinociceptive properties.
Le diagnostic est difficile à faire, les symptômes étant non spécifiques. Adv Healthc Mater 1:348–353.Fabbrini MS, Katayama M, Nakase I, Vago R (2017) Plant ribosome-inactivating proteins: progresses, challenges and biotechnological applications (and a few digressions).
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