Each single-use dose contains a concentration of 100 mg/mL of sugammadex. 5-mL single-dose vial 500 mg sugammadex NDC 0006-5425-15 2-mL single-dose vial 200 mg sugammadex NDC 0006-5423-12 Vials not shown at actual size. Excipient information presented when available (limited, particularly for generics); consult specific product labeling.Solution, Intravenous: Bridion: 200 mg/2 mL (2 mL)Solution, Intravenous [preservative free]: Bridion: 500 mg/5 mL (5 mL) Sugammadex dosing information. For the Consumer. -Satisfactory recovery should be deter… Usual Adult Dose for Reversal of Nondepolarizing Muscle Relaxants: Routine reversal (rocuronium or vecuronium): 4 mg/kg IV once if recovery has reached at least 1 to 2 posttetanic counts (PTC) and no twitch responses to train-of-four (TOF) stimulation Applies to sugammadex: intravenous solution. The Scottish Medicines Consortium, has advised (February 2013) that sugammadex (Bridion ®) is accepted for restricted use within NHS Scotland for the routine reversal of neuromuscular blockade in high-risk patients only, or where prompt reversal of neuromuscular block is required. Routine reversal (rocuronium or vecuronium): 4 mg/kg IV once if recovery has reached at least 1 to 2 posttetanic counts (PTC) and no twitch responses to train-of-four (TOF) stimulation 2 mg/kg IV once if recovery has reached reappearance of second twitch response to TOF stimulation Immediate reversal (rocuronium only): 16 mg/kg IV once Comments: -Dosing is based on actual body weight; the recommended dose does not depend on the anesthetic regimen. Sugammadex doses of up to 16 mg/kg have been associated with increases in activated partial thromboplastin time (aPTT) and prothrombin time/international normalized ratio [PT(INR)] of up to 25% for up to 1 hour in healthy volunteers. Side effects requiring immediate medical attention. Along with its needed effects, sugammadex may cause some unwanted effects. Although not all of these side effects may occur, if … Carefully monitor coagulation parameters in patients with known coagulopathies; being treated with therapeutic anticoagulation; receiving thromboprophylaxis drugs other than heparin and low molecular weight heparin; or receiving thromboprophylaxis drugs and who then receive a … Vials include a …
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