2016;Vaupel P, Harrison L. Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response. Expression of Tie-2 by human monocytes and their responses to angiopoietin-2. 2006;66(2):605–12.Pollard JW. Cancer Metastasis Rev. Macrophage susceptibility to emactuzumab (RG7155) treatment. As the relationship between TAMs and malignant tumors becomes clearer, TAMs are beginning to be seen as potential therapeutic targets in these cases. 2012;336(6077):86–90.Sharma SK, Chintala NK, Vadrevu SK, Patel J, Karbowniczek M, Markiewski MM. 2010;70(14):5728–39.Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. J Clin Oncol. Cancer Cell. A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth.
Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial. Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice. 2017;28(10):2559–66.Cieslewicz M, Tang J, Yu JL, Cao H, Zavaljevski M, Motoyama K, Lieber A, Raines EW, Pun SH. 2007;Cursiefen C, Chen L, Borges LP, Jackson D, Cao J, Radziejewski C, D’Amore PA, Dana MR, Wiegand SJ, Streilein JW. They are heavily involved in cancer-related inflammation. As a matter of fact, several inhibitors and antibodies targeting the TAM recruiting factors are being evaluated in early clinical trials across various types of tumor [,Cancer is more of a systemic disease since metastasis occurs in the majority of patients. 1996;32a(14):2386–93.Metcalf S, Pandha HS, Morgan R. Antiangiogenic effects of zoledronate on cancer neovasculature. 2010;115(7):1461.Xu J, Escamilla J, Mok S, David J, Priceman S, West B, Bollag G, McBride W, Wu L. CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer. As such, therapeutic approaches targeting TAMs are anticipated to be feasible and promising. 2006;177(10):7303–11.Verreck FAW, de Boer T, Langenberg DML, van der Zanden L, Ottenhoff THM. Nat Rev Cancer. Blood. Future Oncol.
Cancer Res. 2016;224:103–11.Kakoschky B, Pleli T, Schmithals C, Zeuzem S, Brune B, Vogl TJ, Korf HW, Weigert A, Piiper A. JXX was involved in the editing of the content and providing the final approval of the version to be published. 2017;10(1):36.Sangaletti S, Di Carlo E, Gariboldi S, Miotti S, Cappetti B, Parenza M, Rumio C, Brekken RA, Chiodoni C, Colombo MP. 2017;35:4.Linehan D, Noel MS, Hezel AF, Wang-Gillam A, Eskens F, Sleijfer S, Desar IM, Erdkamp F, Wilmink J, Diehl J, Potarca A, Zhao N, Miao S, Deng J, Hillson J, Bekker P, Schall TJ, Singh R. Overall survival in a trial of orally administered CCR2 inhibitor CCX872 in locally advanced/metastatic pancreatic cancer: Correlation with blood monocyte counts. A review of trabectedin (ET-743): a unique mechanism of action. Cancer Genomics Proteomics. 2010;21(Suppl 7):vii89–92.Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition.
TAMs affect most aspects of tumor cell biology and drive pathological phenomena including tumor cell proliferation, tumor angiogenesis, invasion and,In addition to VEGF-A, TAMs secrete the pro-angiogenic factors,One of the major functions of TAMs is suppressing the T-cell mediated anti-tumor immune response. 2018;36:5.Nywening TM, Wang-Gillam A, Sanford DE, Belt BA, Panni RZ, Cusworth BM, Toriola AT, Nieman RK, Worley LA, Yano M, Fowler KJ, Lockhart AC, Suresh R, Tan BR, Lim KH, Fields RC, Strasberg SM, Hawkins WG, DG DN, Goedegebuure SP, Linehan DC. 2014;41(1):49–61.Ding HX, Zhao LM, Dai SL, Li L, Wang FJ, Shan BE. J Leukoc Biol.
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